Trump tweeted that he told Bolton Monday night his services were no longer needed at the White House and said Bolton submitted his resignation on Tuesday morning. Trump said that he "disagreed strongly" with many of Bolton's suggestions, "as did others in the administration."
Trump slammed the paper's story on Sunday evening with a familiar response: "Fake News!"
Trump has threatened to shut down the US-Mexico border if the caravan is not stopped, which could seriously disrupt trade.
Trump, who has forged closer ties with Saudi Arabia and the 33-year-old Crown Prince Mohammed bin Salman, acknowledged for the first time on Thursday that Khashoggi, a US resident and Washington Post columnist, had likely been killed.
Trump, 74, a Republican, spent Sunday in Nevada, a state he hopes to wrest away from Democrats after narrowly losing it to Hillary Clinton in 2016. Early in-person voting in the state began on Saturday.
Trump believed that Mexico had done little to stop Central American immigrants on their way to the United States through the Mexican territory, and has even threatened to erect a wall on the southern US border.
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Trump's proposed 25-percent tariff on steel imports and a 10-percent one on aluminum caused stocks to tumble, American economic allies to object, and US farmers to look toward the heavens for relief.
Trump said: "If and when Kim Jong-un chooses to engage in constructive dialogue and actions, I am waiting. In the meantime, our very strong sanctions — by far the strongest sanctions ever imposed — and maximum pressure campaign will continue, as it has been continuing."
Trump had threatened large tariffs on European cars. Last week, Trump said he was ready to impose a "tremendous retribution" against the EU.
Trump said he was making good on US legislation and presidential pledges dating back decades. Other world powers have not done so, sidestepping one of the thorniest disputes between Israel and Palestine.